Effectiveness of Crude Drug Extract of Moringa Oleifera on Hepato Carcinoma: A Cell Line Study

Abstract

Hepatocellular carcinoma (HCC), one of the most prevalent forms of liver cancer, remains a significant global health challenge due to its aggressive nature and limited treatment options. This study explores the potential anticancer properties of crude extracts derived from Moringa oleifera a plant known for its rich phytochemical profile and medicinal properties on HepG2 liver cancer cells. The investigation employed in vitro assays, including MTT and cell migration assays, to evaluate cytotoxic and anti-metastatic effects. The MTT assay revealed a dose-dependent reduction in cell viability, with an IC₅₀ value of 464 µg/mL, indicating cytotoxic potential of the crude extract. Additionally, the cell migration assay demonstrated that it significantly inhibited cell migration, a key process in cancer metastasis. These findings suggest that crude extract exhibits promising anticancer activity against hepatocellular carcinoma through inhibition of cell proliferation and migration, supporting its potential use as a natural therapeutic agent. Further studies involving purified constituents and in vivo models are warranted to validate and optimize its efficacy.